trans – Communicable Diseases Research

From musk to body odor: Decoding olfaction through genetic variation

사향에서 신체 냄새로 : 유전자 변이를 통해 후각을 해독하는

Research Article

Published on 2022-02-032022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

SARS-CoV-2 infection induces beta cell transdifferentiation

SARS-CoV-2 감염은 베타 세포 전환분화를 유도합니다

Clinical and Translational Report

Published on 2021-08-032022-09-10
Journal: Cell Metabolism
[Category] MERS, SARS, 치료기술,

[키워드] Abstract acinar cell addition Alpha Antigen Autopsies Autopsy beta cell Beta cells cause Cell cell fate cell markers cellular cellular stress response chemokines Clinical data coronavirus disease Coronavirus disease 2019 correlation COVID-19 diabetes EgIF2 eIF2 example expression glucagon human islets immunostaining indicated individuals with COVID-19 induce Infection inhibitor insulin islet cell ISRIB lower expression pancreatic pancreatic islet Pathomechanism Pathomechanisms pathway phenotype provide PRSS1 recent reported reversed RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Single-cell RNA sequencing Stress stress response subject subjects suggested susceptible Trajectory analysis Tran trans trypsin 1 Viral Viral antigen
[DOI] 10.1016/j.cmet.2021.05.015 PMC 바로가기 [Article Type] Clinical and Translational Report

Rapid and accurate nucleobase detection using FnCas9 and its application in COVID-19 diagnosis

FnCas9를 이용한 신속하고 정확한 핵염기 검출 및 이를 코로나19 진단에 적용

Article

Published on 2021-07-012022-09-11
Journal: Biosensors & bioelectronics
[Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] accelerated carriers Cas9 cleavage Clinical prognosis clinical sample clinical samples Combination COVID-19 COVID-19 diagnosis COVID-19 outbreak CRISPRDx detection diagnostics disease outbreaks FELUDA FnCas9 heterozygous Infectious disease infectious disease outbreak lateral flow LFA Molecular diagnosis nucleobase nucleotide nucleotide sequence pathogenic point-of-care prototype qPCR Rapid reporter resources robust RT-RPA SARS-CoV2 semi-quantitative sensitivity sequence Sequencing Single nucleotide variant single nucleotide variants SNV SNV detection. SNVs specificity strip Traditional traditional methods trans Uniform variant variants Viral Viral load viral loads
[DOI] 10.1016/j.bios.2021.113207 PMC 바로가기 [Article Type] Article

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

스파이크 당단백질의 DC/L-SIGN 인식은 SARS-CoV-2 트랜스 감염을 촉진하고 글리코미메틱 길항제에 의해 억제될 수 있습니다

Research Article

Published on 2021-05-202022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 바이오마커,

[키워드] ACE2 antigen-presenting cells authentic SARS-CoV-2 virus capture Cell cell lines cell surface CLR CLRs Concentration COVID-19 pathogenesis DC-SIGN defined described dissemination Effectiveness ENhance entry receptor envelope protein evaluated event examined Factor Final glycan glycosylation Host identify immune cells immunomodulation IMPROVE Infection inhibited innate immune response Interaction involved L-SIGN Langerin lung tissue mechanism molecular monocyte Monocytes mucosa opens pandemic Pathogens promote Protein pseudovirus receptor receptors recognize respiratory respiratory mucosa SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike protein SARS-CoV-2 virus SIGN spike spike glycoprotein Spike protein Spread T-lymphocytes target cell target cells tested the cell the SARS-CoV-2 These data trans transfer transmission rate unique Vero E6 VERO E6 cells Viral viral infection viral spike protein virus virus viruses while
[DOI] 10.1371/journal.ppat.1009576 PMC 바로가기 [Article Type] Research Article

Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates

유전적으로 조절된 유전자 발현과 약리학적 라이브러리의 통합은 치료 약물 후보를 제공합니다

Article

Published on 2021-04-262022-09-11
Journal: Human molecular genetics
[Category] 신약개발, 유전자 메커니즘,

A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

SARS-CoV-2에 대한 트랜스 보완 시스템은 독성 없이 진정한 바이러스 복제를 요약합니다.

Article

Published on 2021-04-152022-09-11
Journal: Cell
[Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral biosafety level Biosafety Level 3 BSL-2 laboratory BSL-3 can be used Cell cell line Complementation component coronavirus COVID-19 Culture deleted deletions detectable Diagnosis disease dose envelope gene exhibited expressing gene deletions generate Genes genomic hamster hamsters highest infect inoculated K18-hACE2 transgenic mice level 3 mutated naive cells neutralization ORF3 platform Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus trans transcriptional regulator Vaccine vaccine. Viral viral replication Viral RNA virion virions virulence wild-type SARS-CoV-2
[DOI] 10.1016/j.cell.2021.02.044 PMC 바로가기 [Article Type] Article

Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019

코로나바이러스 질병 2019에서 관련 경로 및 치료 약물의 스크리닝을 위한 통합 생물정보학 분석

Article

Published on 2021-04-012022-09-11
Journal: Archives of medical research
[Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] 2019-nCoV 2019-nCoV coronavirus acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis antiviral drug Antiviral effect antiviral effects approved assist bioinformatics Bioinformatics analysis caused Clinical research Clinical treatment clinically conducted contribute coronavirus Coronavirus infection COVID-19 COVID-2019 database disease drug Effects EGCG Epigallocatechin-3-gallate expression functional enrichment Functional enrichment analysis Genes hub genes Human coronavirus human protein human proteins ingredient inhibit inhibitor inhibitors Integrated analysis Interaction involved mechanism MERS MERS-CoV N protein network analysis Novel coronavirus PKA Previous studies progression Protein reduce Research resveratrol SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. screened Screening selected significant pathways significantly Stage targets therapeutic targets trans trans-resveratrol transcriptional regulation Treatment Vaccine virus
[DOI] 10.1016/j.arcmed.2020.11.009 PMC 바로가기 [Article Type] Article

A novel cell culture system modeling the SARS-CoV-2 life cycle

SARS-CoV-2 수명 주기를 모델링한 새로운 세포 배양 시스템

Research Article

Published on 2021-03-122022-08-13
Journal: PLoS Pathogens
[Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agent Antiviral antivirals approach Author biosafety biosafety level BSL-2 BSL-2 laboratory BSL-3 can be used cause Cell Cell culture cell line cells chloride Complete coronavirus COVID-19 Critical Culture culture system Deletion dissect drug effective evidenced experimental system expresse expressing facilitate genetic recombination genetics genomic GFP global pandemic impede independent intein life cycle MERS MERS-CoV N monensin monensin sodium N gene N protein neutralization nucleocapsid Nucleocapsid gene Particles passage Phosphorylation powerful tool producer cells Protein Proteins replacing Replication replication-competent SARS-CoV-2 reporter reporter gene required Research residue respiratory Salinomycin SARS-CoV SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 virus secure Sequence analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sodium the cells the N protein the SARS-CoV-2 this system trans Transcription vector vectors Viral viral genome viral infection viral life cycle Viral RNA virion assembly Virus life cycle
[DOI] 10.1371/journal.ppat.1009439 PMC 바로가기 [Article Type] Research Article

Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome

COVID-19 관련 사이토카인 방출 증후군 치료에서 IL-6 억제제의 역할

Review

Published on 2021-01-212022-09-12
Journal: International Journal of Medical Sciences
[Category] 진단,

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens
[Category] Biology and Life Sciences, MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression Activation acute respiratory distress acute respiratory distress syndrome ADAM Aggressive angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Angiotensin II AP-1 AT1 Author c-Fos candesartan Candesartan cilexetil cascade Cell cell interactions cells Characteristics chemokines classical combating coordination Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity culture supernatant cytokine cytokine response Cytokine storm Cytokines disease severity down-regulation ectopic expression elevated endothelial Endothelial cell epithelial epithelial cell epithelial cells excessive inflammatory response expressed expressing expression Extracellular generate Host human epithelial cell human epithelial cells human liver hyper-inflammatory response IL-6 IL-6R indicated induce inducer Infection Inflammatory cytokine inhibit inhibited Interaction leads Lung epithelial cells Lung injury Macrophage macrophage activation macrophages MAPK MCP-1 mechanism mediators Monocytes monocytes/macrophage monocytes/macrophages Multi-organ damage NF-κB observation pathology pathway patient sera Phosphorylation primary host pro-inflammatory promote promoted promotion protease protein expression pulmonary epithelial cell receptor receptor antagonist receptor protein receptor signaling referred to Regulatory residue respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Signaling SOCS3 soluble IL-6R Spike protein STAT3 suggested syndrome therapeutic therapeutic intervention tissue damage trans trans-signaling transcriptional transmembrane vascular endothelial cell Viral viral infection viral spike protein with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article